Disease Modification by Combinatorial Single Vector Gene
CombiGene AB (publ), a leading Nordic gene therapy company, today signed an agreement with the Anglo-Swedish Contract Development and Manufacturing Organisation (CDMO) Cobra Biologics for production of candidate drug CG01. Cobra Biologics, part of the Cognate BioServices family and CombiGene announced Cobra has successfully produced and supplied two further DNA plasmids for the production of CombiGene’s gene therapy drug candidate CG01, which is being developed for the treatment of drug-resistant focal epilepsy. CombiGene 's epilepsy project CG01 is now advancing to the final phase of the preclinical program. Following the release of the material from the first large-scale production of CG01 on March 1, CombiGene is now initiating the important preclinical studies in biodistribution and toxicology, two cornerstones of the final preclinical phase, and is planning for the start of the first study in BIOSTOCK: CombiGene on the International Epilepsy Day and the pharmaceutical a.. AQ. 02/03: COMBIGENE Cobra Biologics will produce the AAV viral vector for Combigene’s epilepsy gene therapy from its facilities in Keele, UK.. Nordic gene therapy company Combigene’s CG01 candidate is based on an adeno-associated viral vector (AAV) which administers a combination of neuropeptide Y (NPY) and its receptor Y2 directly to the part of the brain where epileptic seizures begin.
In parallel, the company will intensify preparations for studies in humans, known as clinical studies, which are scheduled to begin in 2022. CombiGene 's epilepsy project CG01 is now advancing to the final phase of the preclinical program. Following the release of the material from the first large-scale production of CG01 on March 1, CombiGene is now initiating the important preclinical studies in biodistribution and toxicology, two cornerstones of the final preclinical phase, and is planning for the start of the first study in CombiGene 's candidate drug, CG01, is being developed for treatment of patients with drug-resistant focal epilepsy. The aim is to enable a very long-term therapeutic effect through a one-time administration. Combigene teams with Cobra and NBR on epilepsy gene therapy by Dan Stanton Friday, October 18, 2019 12:10 pm Cobra Biologics will produce the AAV viral vector for Combigene’s epilepsy gene therapy from its facilities in Keele, UK. Today, CombiGene successfully completed the first large-scale production of its drug candidate CG01, which is being developed for the treatment of drug-resistant focal epilepsy. An agreement was also signed during the week with British Neurochase to optimise the injection strategy and maximise the safety and effect of CG01, which is to be injected directly into human brain tissue.
CombiGene: Analysguiden: Epilepsiprojektet CG01 mot
CombiGene’s epilepsy project The gene therapy company CombiGene has come a long way in the first parts of this process, especially in 2020. In 2022, the company intends to start the first in-human studies, but first, the last preclinical steps must be completed. Cobra Biologics, part of the Cognate BioServices family, an international CDMO manufacturer of biological materials and pharmaceuticals, and CombiGene AB (publ), the leading gene therapy company in the Nordic region, today announced that Cobra has successfully produced master cell banks for the three plasmids used as starting material for CombiGene’s gene therapy CG01. On 15 May 2018, CombiGene announced that Horizon 2020 - EU's Framework Programme for Research and Development - is investing EUR 3.36 million in CombiGene's continued development and commerzialisation of the gene therapy project CG01, which is developed to treat drug-resistant focal epilepsy.
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Feb 9, 2021. Yesterday was International Epilepsy Day which aims to put the spotlight on a devastating disease caused by overactive nerve cells in the brain.
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bengt_westrin – Vi fick frågan CombiGene: Analysguiden: Epilepsiprojektet CG01 mot kliniska studier 2022 BioStock: CombiGene on the International Epilepsy Day and the pharmaceutical för 10 timmar sedan — Collaboration supports progression of Epilepsy Gene Therapy toward clinical trials.
CombiGene – the leading Nordic gene therapy company CombiGene is currently conducting two gene therapeutic development projects: one for treatment of epilepsy that cannot otherwise be treated with drugs and one for treatment of lipodystrophy, a rare condition characterized by an abnormal distribution of fatty tissue in the body.
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In 2016 there were 5.7 million diagnosed epilepsy patients in the USA, the EU5* and Japan. About one-third of these patients do not respond to conventional medical treatment.
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Epilepsiprojektet - combigene
CombiGene’s unique platform uses gene therapy vectors to deliver a combination of neuropeptide y (NPY) and NPY receptors into brain cells which has shown to inhibit epileptic seizures, in a series 2020-08-18 · Cobra Biologics completes production of Master Cell Banks for CombiGene’s epilepsy gene therapy drug candidate. Foundation for future commercial supply of CG01 secured with delivery of three Master Cell Banks Combigene. 179 likes · 20 talking about this. Biotechnology Company BioStock: CombiGene on the International Epilepsy Day and the pharmaceutical authorities' positive response Tue, Feb 09, 2021 08:52 CET. Yesterday was International Epilepsy Day which aims to put the spotlight on a devastating disease caused by overactive nerve cells in the brain. CombiGene is a Swedish gene therapy company that develops a gene therapeutic treatment for epilepsy. This development project is in a late preclinical phase with the first human study scheduled for 2022. BioStock: CombiGene comments the final preclinical steps Fri, Oct 30, 2020 11:05 CET. The gene therapy company CombiGene, which is developing a new treatment for drug-resistant focal epilepsy, is planning to focus on the final preclinical studies next year and then begin the first study in humans in 2022.
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CombiGene begins a proof-of-concept study of CG01 in a chronic epilepsy model. CombiGene is awarded the “Seal of Excellence” by the EU Horizon 2020 framework programme and receives 500,000 kronor from Vinnova. Human expression study confirms that human brain cells can express CombiGene’s candidate drug, CG01. 2018 Yesterday, CombiGene announced the signing of a production agreement with the Spanish gene therapy manufacturer Viralgen for the production of the drug candidate CG01.
Epilepsy is a global problem. The disease affects an estimated 0.6 to 0.8 percent of the world’s population. In 2016 there were 5.7 million diagnosed epilepsy patients in the USA, the EU5* and Japan. About one-third of these patients do not respond to conventional medical treatment.